LADR4 Platform
Revolutionary Smart Drug Development Technology
The Future of Drug Development
LADR4 represents a paradigm shift in pharmaceutical innovation, combining cutting-edge technology with proven scientific principles to accelerate breakthrough therapies.
What is LADR4?
LADR4 — Ligand‑Aided Drug Repurposing, Reprofiling, Repositioning & Rescue — is BKAMhealth’s proprietary methodology to improve drug products by chemically modifying approved drug substances to create new, patentable New Chemical Entities (NCEs).
The Four Pillars of LADR4
Our comprehensive approach combines multiple strategies for maximum impact
Repurpose
Use an existing drug for a new indication.
Reprofile
Create better dosing or pediatric formulations to improve tolerance and efficacy.
Reposition
Modify to overcome barriers (e.g., solubility) so the drug works better, including altering route of dosing.
Rescue
Revive assets that were failing due to absorption/tolerability with chemical modification.
How LADR4 Works
Starting with drug substances already approved for human use, LADR4 applies a modifying agent from a curated library to create an improved, patentable drug. LADR4 is a chemical modification approach (not a formulation) and does not trigger a 505(b)(1) path.
Chemical Modification
Not just formulation changes, but actual chemical modifications that create new molecular entities
Patent Protection
Creates new, patentable New Chemical Entities (NCEs) with extended market exclusivity
Key Advantages
LADR4 delivers unprecedented benefits across all aspects of drug development
Develop ~4× faster than traditional models.
Approx. ~2% of traditional cost basis.
Higher probability of success vs. conventional pathways.
Chemical modification → patentable NCEs; avoids 505(b)(1) 10–12 year, $1–3B path.
Ready to Transform Drug Development?
Join us in revolutionizing how life-saving therapies reach patients faster and more efficiently.